There are a few tips I picked up to maximize your adsense click through rate:
1. Make sure your color codes match your website colors. They should blend in and not stick out.
2. Stay away from from leaderboard image ads, people don’t click them.
3. Look at google’s tips https://www.google.com/support/adsense/bin/static.py?page=tips.html
4. Try to use the best keywords for your ads. Try this tool: http://www.keyworddiscovery.com/?id=22487
5. Don’t worry about clutter caused from your ads. Going all in with ads is normal and will turn off a few readers, but most readers will understand.
6. Bringing targeted traffic, people looking for a certain thing will maximize the amount of money per click. Random traffic means less money per click.